Following the incident, rescuers, police and local people rushed to the site and shifted the bodies and injured to a nearby hospital, where six of them succumbed to their injuries during treatment, said the hospital sources.
A hospital official said that the death toll might further rise as several injured were in critical conditions which include women and children.
The ill-fated van was heading towards the provincial capital of Quetta from the southern port city of Karachi when the accident occurred.
The passenger van was completely destroyed in the accident, reported local media, adding that the bodies of the dead and injured were retrieved after cutting parts of the van.
Police officials in the area said the accident happened due to over-speeding and negligence of the truck driver, and that a case has been registered against the driver over negligence.